24 which is widely found in animals, especially in the brain and nerve tissues, and in the kidney, spleen, skin, liver and bile. 23 It is a derivative of cyclopentane polyphenanthrene. Cholesterol is a sterol lipid with its structure shown in Fig.
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traffic, drugs), 20, 21 military and disaster relief, 5, 22 etc.Īmong the numerous POCT applications, cholesterol detection research is in full swing. 2– 5 POCT is now becoming one of the most promising fields in the in vitro diagnostic industry and is widely used in clinical testing, 6– 10 major epidemic monitoring, 11– 14 individual health management, food safety monitoring, 15– 17 environmental monitoring, 18, 19 on-site law enforcement testing (e.g. 1 With the growing demands for quick, convenient, affordable on-site diagnostic information, POCT has gained more and more attention both in academia and industry. This concept was brought to the public since the late 20th century and early 21st century. Point-of-care testing (POCT) is a laboratory-medicine discipline which endeavors to make diagnostic techniques and instruments, which is easily accessible at patient's beds, in outpatient clinics, at sides of accidents or even at patient's home. Above all, the enzymatic strip detection of serum total cholesterol for POCT presents promising prospects for the fast cholesterol monitoring and will be further developed after those issues being addressed. Considering the current social demand and production issues, the colorimetric method is more likely to achieve mass production. It comprises the advantages of POCT, necessity of cholesterol testing, current status using colorimetric and electrochemical method, challenges and future prospect. This review summarizes the research on enzymatic strip detection of serum total cholesterol for POCT by colorimetric and electrochemical method, which may guide further research.
Combing with the advantages of point-of-care testing (POCT), enzymatic strip detection of serum total cholesterol is continuously being widely used. To address this issue, the enzymatic strip detection may provide an optimal approach. However, the abnormal level of cholesterol requires long-term and sensitive monitoring, which can be time-consuming and laborious for the patients to go to the hospital for the medical examination.
Redundant cholesterol in human blood can cause severe health problems such as heart disease, coronary artery disease, arteriosclerosis, hypertension, cerebral thrombosis, etc Simple and fast cholesterol determination in blood is essential and benefit for early diagnosis.